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Parley: Pharmacotherapy of Asthma (Lung Biology in Health and Disease)

Pharmacotherapy of Asthma (Lung Biology in Health and Disease)
Standing as the only text focused on the pharmaceutical treatment of asthma, this reference details the pharmacology, mechanisms of action, efficacy, and safety of every drug currently utilized in the management and care of asthma…

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Treating and Managing Asthma

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Atomic Force Microscopy (AFM) image of the designed extracellular matrix. (Credit: Image courtesy of National Physical Laboratory)

The extracellular matrix (ECM) provides the physical and chemical conditions that enable the development of all biological tissues. It is a complex nano-to-microscale structure made up of protein fibres and serves as a dynamic substrate that supports tissue repair and regeneration.
Self-assembling peptide fibres that have similar properties to those of the native matrices are of particular interest. However, these near-crystalline nanostructures fail to arrange themselves into interconnected meshes at the microscopic scale, which is critical for bringing cells together and supporting tissue development.
To solve this problem, a research team at NPL designed a small protein consisting of two complementary domains (structural units) that promote the formation of highly branched networks of fibres that span microscopic dimensions. The team showed that the created matrix is very efficient in supporting cell attachment, growth and proliferation.

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Stomata are normally evenly spaced for photosynthetic gas exchange, as in the normal Arabidopsis seedling shown at the top left. In a plant lacking all ERECTA-family receptor kinases (top right), excessive stomatal clusters result. Treating normal seedlings with EPF1 (bottom right) or EPF2 (bottom left) alters stomatal development.
“Stomata are really vital for plant growth and survival,” says Keiko Torii, a Howard Hughes Medical Institute - Gordon and Betty Moore Foundation investigator at the University of Washington who led the new work, which was published online January 12, 2012, in the journal Genes & Development.
…..“Some of our mutants that have fewer stomata still grow just fine under normal conditions and they lose much less water,” says Torii. “So it will be interesting to study this in crop plants and see the relationship is between stomatal density and plant productivity.” Tweaking the density of a crop plant’s stomata could offer farmers a way to save water, she says.

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